ResourceLife Sciences
FLIPR Penta high-throughput cellular screening system
31 Jul 2023In this application note, Molecular Devices® describes the anatomy and applications of its FLIPR® Penta high-throughput cellular screening system.
The applications of this system include:
- GPCR: Monitor GPCR activity and corresponding intracellular second messenger changes (calcium and cAMP) using fluorescence and luminescence cell based assays
- Membrane potential: Observe real-time membrane potential changes associated with ion channel activation and ion transporter proteins
- Cardiomyocytes: Observe calcium flux to assess cardiotoxicity in the early stages of drug discovery
- Potassium channels: Measure functional activity of ligand- and voltage-gated potassium channels
- Ligand-gated calcium channels: Measure the change of global intracellular calcium, in response to the activation of ion channels
- 3D assays: Detect calcium oscillations in 3D cardiomyocyte and neuronal, providing a biologically relevant assay system to assess potential new pharmaceutical treatments and environmental toxins
- Biochemical assay: Enable fast 'inject and read' kinetic enzyme assays, increasing the throughput of biochemical assays compared to standard plate readers
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Cell Adhesion AssaysCell adhesion assays are used to quantitate attachment and analyze the molecular mechanisms for extracellular matrix adhesion, cell migration and sensitivity to inhibitors. Find the best cell adhesion assay equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Cell AnalysisThe analysis of cells allows researchers to understand the factors which contribute to cell health and function. These influencing processes can then be predicted and altered, leading to the development of medication and disease treatments.Membrane ProteinsIon Channel