ResourceLife Sciences
Flexible nanoparticle development: process optimization & scale-up of a wide range of synthetic nanomedicines with Sunshine
17 Oct 2023In this application note, Unchained Labs presents Sunshine for nanoparticle development. Nanomedicine, utilizing synthetic nanomaterials like liposomes, lipid nanoparticles (LNPs), and polymer nanoparticles, holds significant promise in drug delivery. These materials enhance the solubility, stability, and bioavailability of active pharmaceutical ingredients (APIs), allowing improved API transport across cell membranes and extending in vivo circulation time, thereby enhancing efficacy and safety. Due to the diverse physicochemical properties of APIs, a flexible nanoparticle generation process is crucial. Sunshine offers an automated microfluidic approach, enabling the development and optimization of milliliter-scale nanoparticle synthesis protocols for various material types and particle structures. It also has the capacity for continuous manufacturing in multi-liter quantities, facilitating pre-clinical testing of a wide range of APIs.
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