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Faster Drying of HPLC Fractions

2 Oct 2017

If you're carrying out HPLC purification, then at some point you'll need to dry a solution of Acetonitrile/Water or Methanol/Water. This is actually one of the most complicated solvent mixtures to dry, and many users, unaware of the best way to do it, take far longer than they need to, to dry their solutions. Genevac Evaporators have special features that enable you to get the job done quickly and effectively while all the time providing the unique Genevac "SampleGuard" protection that prevents your sample ever exceeding a safe temperature. This application note describes drying techniques that apply equally to Acetonitrile/Water or Methanol/Water.

Series 3 HT Evaporator

Genevac

The all new Series 3 HT evaporator range from Genevac represents the ultimate in solvent removal technology. The latest touchscreen technology, new high performance vacuum pump, and a sleek ergonomic design makes optimising your evaporation processes effortless. High speed, High throughput evaporation Front opening for easy access. New intuitive touchscreen control system for ultimate ease of use Integral condenser meaning a smaller system footprint Rugged design with clean lines and a modern look All the features and functionality you expect from a Genevac HT evaporator including Dri-Pure anti-bumping, automatic end of run, HCl resistance, Inert Gas Purge, Lyospeed and EXALT controlled crystallisation Available in HT-6 and HT-12 format, Series 3 HT evaporators feature a new 6 place rotor which accepts all existing Genevac HT series holders. Sample formats include microtitre plates, tubes, vials, flasks and SampleGenie -  unique flask and sample holder technology which enables large volume samples to be dried or concentrated directly into the small vial of your choice. Intuitive touchscreen controls enhances monitoring and review of the whole evaporation process. For popular solvent removal protocols pre-set 'Press & Go' methods makes operation easy and productive even for occasional users. Simplified manual and automatic programming means even the most complex multi-stage evaporation methods can be set-up and run quickly and easily. Genevac HT Evaporators are designed to provide the ideal solution for evaporation bottlenecks in the drug discovery laboratory. High performance and high sample capacities make them the ideal workhorses for the busy medicinal chemistry laboratory. Applications: High Throughput Chemistry and Parallel Synthesis LC/MS or HPLC Purification Fast Lyophilisation of purification fractions Natural Products Research Oligosynthesis Flash Chromatography Process Development.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.Evaporators and Freeze DryersCentrifugal evaporation is used for solvent removal from a sample. This is a useful technique for sample concentration or sample drying. Many centrifugal evaporators are modular with a central vacuum pump for generating low pressure. Useful features of evaporators or vacuum ovens include minimal solvent bumping, solvent resistance, computer control, temperature regulation and benchtop design.HPLCHigh-performance liquid chromatography (HPLC) is a technique for separating, identifying, and quantifying components in mixtures. It is widely used in chemical, pharmaceutical, and environmental analysis to ensure purity and identify unknown compounds. Explore the best HPLC systems in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers.Solvent Evaporation
Faster Drying of HPLC Fractions