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Fast Molecular Interaction Screening of Epigenetic Gene Regulator G9a with Fragments from a Large Chemical Space
12 Feb 2019Dianthus swiftly detects and quantifies molecular interactions in solution, independent of the molecular mass of the two interacting molecules, making it a perfect match for fragment-based screening with compounds representing a large chemical space. In this application note, data from single-dose screening of a fragment library is shown with a broad molecular mass and complexity range against the target molecule histone methyltransferase (HMT) G9a, followed by affinity constant determination (Kd) for a selection of hit molecules.
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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.Compound ScreeningCompound screening is a method used to discover specific compounds that could be promising candidates for pharmaceutical use. This potential is identified when compounds interact with the target protein during screening and could therefore be carried forward in the drug development process.Drug Discovery & Development Screening