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Explore the InSphero MASH CALL initiative

InSphero
3 Nov 2023

In this application note, explore the InSphero MASH CALL initiative, a fast and cost-effective identification of drug candidates in MASH (Metabolic Dysfunction-associated Steatohepatitis, renamed from NASH). Furthermore, discover how the 3D InSight™ Liver Microtissue MASH model is a robust, reproducible and translational model that can recapitulate human hallmarks of MASH predictive of clinical candidates.

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3D InSight™ Human Liver Microtissues

InSphero

Discover the 3D InSight™ Human Liver Microtissues: the gold standard for Hepatotoxic screening. Pharma-validated co-culture models offer 2x higher DILI prediction sensitivity than 2D hepatocytes. Features pooled PHH from male/female donors co-cultured with Kupffer cells and LECs, 28-day viability, in 96-well format. Includes 50mL 3D InSight™ Liver Maintenance Medium. Check the bi-weekly production schedule online. 

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drug TestingIt is essential to test the efficacy and toxicity of drugs at every stage of their development to ensure that a pharmaceutical product is fit for purpose and safe for use before reaching the stage of mass production and distribution.Microtissue

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Explore the InSphero MASH CALL initiative