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Explore the importance of therapeutic oligonucleotides in pharmaceuticals, which require specialized ion-pair reversed-phase chromatography
14 Sept 2023In this application note from Phenomenex, explore the industry gold standard Clarity® OTX sample prep combined with the proven reliability of Biozen™ Oligo for analytical characterization of oligonucleotides.
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Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.Oligos