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Exploratory Urinary Metabolomics Study of Type 1 Leprosy Reactions in Nepal
19 Aug 2015Leprosy is a contagious, infectious disease initiated by Mycobacterium leprae (M. leprae) and often resulting in severe, life-long disabilities that presents with different clinico-pathological forms. Presented in this scientific poster is an exploratory metabolomics study of a prospective longitudinal cohort recruited in Nepal during 2008-2013, in an attempt to identify associations between urinary metabolic patterns and leprosy with or without reactions. Urine samples were analysed by UHPLC-ESI-TOF MS, Bruker Daltonics.
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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MetabolomicsMetabolomics is the study of small metabolites (the intermediates and products of metabolism). It involves the identification and quantification of cellular metabolites using analytical technologies such as GC, HPLC, NMR, and LC/MS.Infectious DiseaseInfectious disease diagnostics refers to the isolation and identification of causative agents, such as viruses, bacteria or fungi. Diagnostic tests include bacterial culture, microscopy, chemistry assays, molecular diagnostics and MALDI-TOF. Tests can be carried out in the laboratory or at the point-of-care.Human UrineHuman urine can be used in a number of tests for human health diagnosis, treatment assessments and the detection drug use. Techniques used with Human urine include LC-MS/MS, SLE, GC-MS, SPE and mass spectrometry.UrineThe analysis of urine is important in medicinal, anti-doping, forensic and life sciences applications. The ability to evaluate what someone has ingested through their urine enables fast detection and diagnosis of certain illnesses.