Exploiting the potential of HoloMonitor digital holographic microscopy by combining it with 3D matrix cell culture assays

In this application note, a different type of microscope, HoloMonitor M4, based on digital holography, has demonstrated high compatibility with 3D Matrigel cell cultures. PHI researchers were able to quantify wound closure and cell movement in Matrigel by single-cell tracking. Researchers at PHI also found possibilities for further applications, such as analysis of drug response, tumor growth, metastasis, and invasion, in our 3D preparations.