Enhanced ELSD Sensitivity of Volatile Compounds via Nebulization Gas Substitution

This poster describes an improved technique for reaction monitoring in synthetic chemistry, as well as drug discovery and natural product research. Typical ELSDs can easily detect non-volatile compounds; however, semi-volatile compounds can be difficult to detect without fine tuning detection parameters. In order to detect semi-volatile compounds successfully, special considerations during the design phase of the detector are required. If the ELSD is designed correctly, substituting helium for nitrogen enables the detection of semi-volatile compounds, which improves sensitivity and lowers detection limits for semi-volatile moieties while still permitting evaporation of the column elution solvents.