ResourceLife Sciences
Electrophysiology and Calcium Imaging; Pain Perception from Sensory Transduction Sites.
23 Jul 2015Traditionally, all recordings from nerves that detect pain have been made outside the organ of interest, as these nerves project toward the spinal cord. This case study aimed to identify and record directly from the nerve endings that detect pain from internal organs, from the site where sensory transduction occurs, using calcium imaging to record dynamic changes in excitability from multiple sites along single axons that underline pain perception.
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ElectrophysiologyElectrophysiology is the study of biological voltage changes, from a single ion channel through to a whole organ scale. Voltages can be measured using patch clamping, automated workstations, electrophysiology rigs or cell based assays. Specific cell lines, manipulators and microinjectors are also available for electrophysiology research.Electron MicroscopyElectron microscopes (EM) are used to create high-resolution images of samples at the nanoscale by means of an accelerated beam of electrons as a source of illumination. Types of electron microscope include scanning electron microscopes (SEM), transmission electron microscopes (TEM), scanning transmission electron microscopes (STEM) and cryo-electron microscopes. Focused ion beam (FIB) microscopes are useful for modifying or milling a sample surface with nanometer precision, as well as imaging. Find the best electron microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.CalciumEMCCDCCD cameraPain ManagementNeuronsNeurons are the fundamental units of the brain and nervous system, involved in transmitting information. Understanding neuron function is critical in neurobiology, neuroscience, and neurodegenerative disease research. Explore neuron research tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Pain Perception