ResourceLife Sciences
Electrophysiological recordings of Ec-ClC activity on the SURFE²R N1
24 Nov 2020In this application note, Nanion presents Ec-ClC activity measurements on the SURFE2R N1 instrument using proteoliposomes reconstituted with purified Ec-ClC at different lipid-to-protein ratios. This assay can easily be adapted for other transporters of the ClC family and provides a useful tool in future drug discovery.
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SURFE²R N1
Nanion Technologies GmbHThe SURFE²R N1 is an automated analysis device for the measurements of electrogenic transporters (symporters, exchangers and uniporters) and pumps. It employs the label-free, SSM-based electrophysiology technology, achieving a throughput of 150 datapoints per day.
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ElectrophysiologyElectrophysiology is the study of biological voltage changes, from a single ion channel through to a whole organ scale. Voltages can be measured using patch clamping, automated workstations, electrophysiology rigs or cell based assays. Specific cell lines, manipulators and microinjectors are also available for electrophysiology research.