Drug metabolism in a gut-liver microphysiological system
23 Mar 2021In this application note, CN Bio applies a multi-organ gut-liver MPS to recapitulate the kinetics and metabolism of the anti-inflammatory compound diclofenac.
Download the full protocol below to explore how this model can enable the accurate characterization of drug pharmacokinetics and be used to better predict appropriate drug dosing regimens.
Related products
Request Quote for All Products
The PhysioMimix™ OOC Range of Single and Multi-organ Microphysiological Systems (MPS) by CN Bio
CN BioPhysioMimix™ microphysiological systems generate in vitro microtissues that mimic the structure and function of human tissues and organs. Through the simulation of human biological conditions, they bridge the gap between traditional cell culture and human studies, reliably predicting drug effects to facilitate the accelerated development of safe and efficacious therapeutics.
Multi-chip Dual-organ (MPS-TL6) Plates by CN Bio
CN BioMulti-chip Dual-organ (MPS-TL6) consumable plates from CN Bio are used to culture interconnected 3D in vitro multi-organ-on-chip models under perfusion, such as Gut/Liver, or Lung/Liver, to generate clinically translatable data.