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Differential recovery of gabapentin and pregabalin utilizing SPE extraction demonstrated in a 43-analyte urine confirmatory LC‑MS/MS panel
27 Sept 2020This poster describes an SPE extraction method followed by LC-MS/MS analysis for the complete recovery of gabapentin and pregabalin from urine while not impacting the complete recovery of most other analytes. This differential recovery can reduce the complications associated with samples with high concentration gabapentin and pregabalin, such as off-scale chromatography, carryover, and ion suppression.
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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.UrineThe analysis of urine is important in medicinal, anti-doping, forensic and life sciences applications. The ability to evaluate what someone has ingested through their urine enables fast detection and diagnosis of certain illnesses.