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Developing New Methods for Pesticides in Dietary Supplements

Restek Corp.
1 Apr 2011

In this application note a procedure is demonstrated that incorporates a QuEChERS extraction, cSPE cleanup and GCTOFMS, resulting in good recoveries for a wide range of pesticide chemistries in dandelion root powder. This approach saves time and can reduce analyst variation by minimizing manual preparation with prepackaged extraction salts and snap-and-shoot standards. Analytical benefits include reduced interferences and good recoveries, even of polar compounds.

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Q-sep™ QuEChERS Tubes

Restek Corp.

Q-sep™ QuEChERS Tubes for Pesticide Residue Analysis • Fast, simple sample extraction and cleanup using dSPE. • Fourfold increases in sample throughput. • Fourfold decreases in material cost. • Convenient, ready to use centrifuge tubes with ultra pure, preweighed adsorbent mixes. Quick, Easy, Cheap, Effective, Rugged, and Safe, the QuEChERS ("catchers") method, developed by the USDA Eastern Regional Research Center, has become very popular for extraction and clean-up of pesticide residue samples. Our products are available in three centrifuge tube sizes to meet the needs of both extraction and cleanup of a wide variety of sample matrices following various methods. The researchers developed a simple two-step procedure. First, the homogenized samples are extracted and partitioned, using an organic solvent and salt solution. Then, the supernatant is further extracted and cleaned, using a dispersive SPE technique. Multiple adsorbents are placed in a centrifuge tube, along with the 1mL of organic solvent and the extracted residues partitioned from step 1. The contents are thoroughly mixed, then centrifuged, producing a clean extract ready for a variety of GC or HPLC analytical techniques. Validation and proficiency data for the QuEChERS method are available for a wide variety of pesticides in several common food matrices on their website.

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Rxi®-5Sil MS (Fused Silica) Columns

Restek Corp.

Rxi® fused silica capillary GC columns were designed specifically to be the best columns available, for exceptional inertness, ultra-low bleed, and reproducible retention and selectivity.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Labware and Lab SuppliesLabware and lab supplies include various forms of glassware, plasticware, reagents and personal protective equipment (PPE) and are used across all scientific laboratories, enabling daily tasks to be performed. Explore a range of flasks and beakers, petri dishes, carboys and storage bottles. Labware such as condensers, desiccators and burettes are also available for more specific tasks. Find the best labware and lab supplies in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Environmental Monitoring and TestingEnvironmental monitoring and testing uses handheld portable analyzers, kits, spectrometers or chromatography systems for air, water, soil, food and other sample testing. Useful features of analyzers such as BOD and COD include portability, easy calibration, automation and sensitivity.  Environmental test kits for pH, water, moisture, etc, should be accurate, sensitive, reliable, fast and easy to use.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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