ResourceSpectroscopy
Determination of Residual Solvents in Pharmaceutical Products Using Static Headspace and Time of Flight GC/MS
16 Jan 2015The USP 467 method is widely used for the identification and quantification of residual solvents in pharmaceutical products. In particular the USP 467 describes the use of static headspace sampler coupled with a GC-FID system in order to recognize and quantify organic volatile impurities. This poster shows the benefits obtained using the Headspace technique coupled with a GC/TOF-MS system capable of analyzing all classes of compounds in a single analysis drastically reducing the time analysis.
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GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.RegulatoryPharmaceutical regulations impact on all areas of drug development, manufacture and control and supply. Services are provided from the early stages of drug development and clinical trials through to dossier submission, approval and marketing. Regulatory also includes submission of analytical studies from the pharmaceutical product and safety. PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.Solvent Monitoring