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Determination of moisture in a protein sample using a portable NIR instrument

Thermo Fisher Scientific
8 Mar 2018

In this feasibility study the performance of a portable NIR instrument was evaluated to monitor moisture levels within a protein sample, as proof of concept to monitor lyophilized samples in a pharmaceutical process. Specifically, a multivariate PLS model was developed and evaluated for the ability to predict the levels of moisture in a casein protein. The spectra were collected in diffuse reflectance mode using a portable NIR instrument. The use of a portable instrument is also evaluated and compared with a lab based NIR instrument in order to show the utility of the portable instrument.

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microPHAZIR RX

Thermo Fisher Scientific

The Thermo Scientific™ microPHAZIR™ RX Analyzer is a handheld Near-Infrared (NIR) instrument designed for rapid, on-site raw material identification.   Pharmaceutical manufacturers can obtain reliable material identity verification anywhere in the plant within seconds. The microPHAZIR RX Analyzer provides a portable tool to meet regulatory requirements, improve product quality, cut manufacturing costs, and reduce supply chain risk.  

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Near Infrared SpectroscopyNear-infrared (NIR) spectroscopy measures the interaction of near-infrared light with a sample, including transmission, reflectance and absorbance, facilitating the identification of analytes. Measurements can be conducted using a Fourier-transform near infrared (FT-NIR) spectrometer, while there are also UV-Vis- NIR spectrophotometers that measure a broader spectrum of wavelengths. Find the best NIR spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.RegulatoryPharmaceutical regulations impact on all areas of drug development, manufacture and control and supply. Services are provided from the early stages of drug development and clinical trials through to dossier submission, approval and marketing. Regulatory also includes submission of analytical studies from the pharmaceutical product and safety. Quality ControlQuality control is needed in all production processes. Quality control is a monitoring procedure or set of procedures that are put in place to ensure that a manufactured product adheres to a defined set of quality criteria. NIRSUV-Visible-NIRUV-Visible-NIR spectroscopy is used to analyze a wide range of samples based on their absorption of ultraviolet, visible, and near-infrared light. It is commonly applied in chemical analysis, material science, and quality control. Browse our peer-reviewed product directory to find the best UV-Visible-NIR spectroscopy systems, compare products, check reviews, and get pricing directly from manufacturers.SpectroscopySpectroscopy is a technique that analyzes the interaction of light with matter to study molecular properties, concentrations, and structural information. Widely used in chemical, pharmaceutical, and environmental analysis, spectroscopy offers insights into molecular composition and helps identify unknown compounds. It plays a key role in quality control, research, and diagnostics. Browse our peer-reviewed product directory to compare spectroscopy tools, read reviews, and get prices directly from manufacturers.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.Moisture AnalysisManufacturingManufacturing is the production of merchandise for use or sale using labor and machines, tools, chemical and biological processing, or formulation.

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