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Detection of an expanded SAMHSA pre-employment panel by LC-MS

Thermo Fisher Scientific
12 Nov 2023

The Substance Abuse and Mental Health Services Administration (SAMHSA) is an agency within the US Department of Health and Human Services (HHS) responsible for establishing the Mandatory Guidelines for Workplace Drug Testing Programs for federally regulated employees. These guidelines define which drugs are included in the program and what cutoffs are used to determine a positive result. Any laboratory that wishes to become an HSS-Certified laboratory must be able to meet these testing guidelines. Fast, sensitive, and robust methods are necessary to meet the throughput demands of these certified laboratories. In this poster from Thermo Fisher Scientific, explore a highly sensitive and robust LC-MS/MS analytical method that has been developed for the quantitation of 19 common drugs of abuse in urine via a four-minute gradient.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Drugs of AbuseA drug of abuse is a drug that has been taken for non-medical purposes. Such drugs can have mind-altering effects, with some causing dependence and addiction.

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Detection of an expanded SAMHSA pre-employment panel by LC-MS