ResourceLife Sciences
Designing non-terminal longitudinal mouse studies
14 Nov 2023In this application note from Olink, explore how using 1 µL of sample for comprehensive cytokine profiling significantly advances biomarker analysis, enhancing consistency in longitudinal mouse studies and adhering to ethical standards for minimal animal use. This method offers researchers flexibility in selecting specific time points, allowing for more frequent and nuanced observations of cytokine changes. This small volume profiling technique is a transformative tool for preclinical research, combining technical innovation with ethical consideration.
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BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.CytokinesCytokines are signaling proteins critical for cell communication in the immune system. They regulate inflammation, immune responses, and cell growth. Cytokine research is vital for understanding disease mechanisms and developing therapies. Explore tools for cytokine detection and analysis in our directory.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.