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Definitive EtG/EtS LC-MS/MS Analysis: A Rugged 4-Min Method for High-Throughput Labs

Restek Corp.
7 May 2019

Methods for monitoring alcohol consumption biomarkers EtG and EtS are generally limited by poor retention and coelution with matrix interferences, as well as by long analysis times and short column lifetimes. The dilute-and-shoot EtG/EtS LC-MS/MS analysis developed here using the novel Raptor EtG/EtS column easily resolves EtG and EtS from matrix interferences, providing consistent, accurate results for high-throughput labs testing human urine samples for alcohol consumption.

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Raptor EtG/EtS LC Column

Restek Corp.

Restek chemists became the first to combine the speed of superficially porous particles (also known as SPP or ""core-shell"" particles) with the resolution of highly selective USLC technology. This new breed of chromatographic column allows you to more easily achieve peak separation and faster analysis times with existing HPLC and UHPLC instrumentation.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Alcoholic BeveragesThe analysis of alcoholic beverages involves testing their composition, quality, and safety, including alcohol content, flavor compounds, and impurities. This is essential for quality control and regulatory compliance. Explore tools for alcoholic beverage testing in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Human UrineHuman urine can be used in a number of tests for human health diagnosis, treatment assessments and the detection drug use. Techniques used with Human urine include LC-MS/MS, SLE, GC-MS, SPE and mass spectrometry.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.

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Definitive EtG/EtS LC-MS/MS Analysis: A Rugged 4-Min Method for High-Throughput Labs