SelectScience
Join Free
Accelerating Science
ResourceLife Sciences

Data-driven CHO bioprocess optimization and scale-up

908 Devices
10 Oct 2024

Chinese hamster ovary (CHO) is the most widely used and well-understood cell type for monoclonal antibody (mAb) production. 908 Devices performs a data-driven optimization of a bioprocess, achieving process development goals with regards to titer, toxic metabolite profiles, and viability. Discover how a combination of analytical tools including 908 Devices’ REBEL and MAVEN were used to provide access to unique insights, informing this process.

Related products

Request Quote for All Products

REBEL

908 Devices

At-line cell culture media analysis. Results on 30+ components in under 10 minutes. When and where is your call. With the REBEL, now is always on the table.

(1)

MAVEN

908 Devices

MAVEN gives you automated, don’t-even-sweat-it, on-line monitoring of glucose and lactate concentrations in cell culture and fermentation processes. Get real-time process insights and dynamic control of substrate feeding without the loss of bioreactor volume.

(0)

Links

908 DevicesCompany website

Tags

Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.Scale-upScale-Up is generally defined as the process of transferring the results of the discovery phases of the drug discovery process, obtained on a laboratory scale, to the pilot plant and finally to production scale. Scale-Up uses reactors and pump systems as well as reagents, standards and buffers. Often Scale-Up is provided as a service by Contract Manufacturing Organizations (CMOs). CHOProcess OptimizationProcess optimization involves improving the efficiency, cost-effectiveness, and quality of processes in various industries, including manufacturing, pharmaceuticals, and biotechnology. Explore process optimization solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

Related resources

Data-driven CHO bioprocess optimization and scale-up