ResourceLife Sciences
Cryo-Confocal Imaging with Airyscan Improving Resolution and Signal-to-Noise in Cryo-Fluorescence Microscopy
15 Jun 2015A major limitation for correlative cryo-fluorescence microscopy is the current unavailability of cryo-immersion optics that could yield a higher numerical aperture. In this application note, combining ZEISS LSM 880 with Airyscan and cryo-fluorescent imaging, allowed data to be obtained with a significant increase in resolution and signal-to-noise compared to standard confocal images under cryoconditions.
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ZEISS LSM 880 with Airyscan
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Light MicroscopyLight microscopes or optical microscopes are used to visualize microscale objects under magnification, including cells, clinical specimens and materials. Lab equipment for light microscopy includes confocal microscopes, fluorescence microscopes, zoom and stereo microscopes. Microscope slides and imaging reagents are available for visualizing samples, as well as various microscope stages and incubators for large or temperature-sensitive samples. Find the best light microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Fluorescence MicroscopyFluorescence microscopy has become an essential tool in biology, as well as in materials science. The application of many fluorochromes has made it possible to identify cells and sub-microscopic cellular components with a high degree of specificity. Using multiple fluorescence labels, different probes can simultaneously identify several target molecules.