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CQA analysis for AAV drug production by multiple workflows on a single CE platform

SCIEX
3 Jul 2025

Adeno associated viruses (AAVs) are used widely in the development of gene therapies for viral vectors due to their safety and effective in delivery of therapeutic genes to patients. Monitoring the critical quality attributes (CQAs) of your AAV therapeutic is therefore critical to meet safety and efficacy and can be performed using capillary electrophoresis.

Discover the BioPhase 8800 system from SCIEX that offers multiple workflows for assessing different CQAs across the AAV production process. Explore its key features and how it can provide reproducible and high-precision results.

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BioPhase 8800 system

SCIEX

Purpose-built to target quality and efficiency, the BioPhase 8800 system enables parallel sample throughput and analysis for capillary electrophoresis characterization. 

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Capillary ElectrophoresisCapillary electrophoresis (CE) is used to separate molecules based on charge, size and hydrophobicity. Pressure, voltage or a vacuum is used to introduce the sample to fused silica capillaries. Fluorescence, UV/Vis, UV or diode array detectors are used to visualize components. Types of CE systems include capillary electrochromatography (CEC), capillary zone electrophoresis and capillary gel electrophoresis. Find the best capillary electrophoresis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein ExpressionProtein expression is the utilization of cell machinery for the synthesis of proteins and has become a critical tool in biotherapeutic, genomic, and proteomic research. Produce recombinant proteins with expression vectors in combination with a host cell suitable for high-level protein expression. For production of toxic proteins, consider cell-free expression vectors. Create and monitor post-translational modifications with protein modification kits. Find the best protein expression products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.aavGene TherapyGene therapy is a technique that modifies or replaces genes within an individual's cells to treat or prevent diseases. This approach holds potential for curing genetic disorders, cancers, and certain viral infections. Advances in gene editing technologies like CRISPR are driving the growth of gene therapy. Explore gene therapy tools and technologies in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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CQA analysis for AAV drug production by multiple workflows on a single CE platform