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Contichrom CUBE: A bench top chromatography system for batch and continuous processing

YMC America, Inc.
21 Mar 2023

In this product brochure from YMC Americas, Inc., learn more about the Contichrom® CUBE System, a flexible purification system for process development of (bio-)pharmaceuticals such as monoclonal antibodies, peptides, and oligonucleotides. The CUBE system enables single-column batch and twin-column counter-current processes, such as capture (CaptureSMB®) for monoclonal antibody (mAb) affinity chromatography and MCSGP for peptide. Additionally, the N-rich process functionality allows the rapid isolation of product-related impurities for CMC development. The systems are offered with pump flow rates of up to 36 mL/min or 100 mL/min.

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Contichrom® CUBE

YMC America, Inc.

The Contichrom CUBE is a benchtop continuous chromatography system for process development of (bio-)pharmaceuticals.  The five-in-one functionality includes single-column and integrated batch chromatography, as well as twin-column counter-current processes such as capture (CaptureSMB®) for monoclonal antibodies and MCSGP for peptides and oligonucleotides.  Additionally, the N-Rich® process functionality allows the rapid isolation of product-related impurities for CMC development. 

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.Antibody PurificationChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.PeptidesPeptides are short chains of amino acids that play key roles in biological processes, including signaling, immune responses, and enzyme regulation. Peptide research is critical in drug discovery, diagnostics, and vaccine development. Browse our peer-reviewed product directory to find the best peptides and peptide-related products, compare options, check reviews, and get pricing directly from manufacturers.

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