ResourceLife Sciences
Conjugating antibody to drug using ThioBridge technology for better ADCs
19 Feb 2024In this application note, explore how ThioBridge®, a conjugation technology, enables precise and site-specific modification of antibody interchain disulfide bonds, without the need for antibody engineering. As a next-generation approach, ThioBridge addresses the shortcomings of first-generation conjugation technologies, allowing more homogeneous, reproducible antibody–drug conjugates (ADC) constructs with a more uniform drug–antibody ratio (DAR) profile compared to first-generation technologies.
Links
Tags
AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.