Complementary Selectivity for HPLC and LC-MS Separation of Polar Hydrophilic Compounds with SeQuant® ZIC®-cHILIC from Merck Millipore

This new zwitterionic stationary phase with phosphorylcholine functional group provides you with complementary selectivity for easier method development for substances that have been difficult to separate by previous types of HPLC columns operated in reversed-phase or HILIC mode. The selectivity features of SeQuant® ZIC®-cHILIC are especially beneficial for negatively charged polar compounds such as nucleotides and organic acids, but do also provide advantageous separations of positively charged hydrophilic molecules; for example aminoglycosides and cations.   The column is also very suitable for zwitterionic and neutral polar hydrophilic substances. High-performance HILIC column Complementary selectivity for polar hydrophilic compounds Maximum LC-MS compatibility with minimized column bleed Excellent reproducibility and robustness Very high stability (more than 1600 injections during 270 hours of continuous use without showing any signs of change in retention)