ResourceLife Sciences
Comparison of PerkinElmer Vascular Pre-clinical Fluorescent Imaging Agents in Oncology and Inflammation Research
23 May 2014Optical-based in vivo imaging of blood vessels and vascular leak is an emerging modality for studying changes that occur in a variety of different cancers and inflammatory states. Imaging agents that fluoresce in the near infrared (NIR) are particularly useful for detection of changes in vascular permeability because of relatively low tissue absorbance, permitting effective penetration into deep tissue sites. In this application note three NIR fluorescent agents were compared. Superhance, AngioSense and AngioSPARK show clear differences in physicochemical properties, blood pharmacokinetics, optimal imaging time points, tissue clearance, and overall efficacy in tumor and inflammation imaging.
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In Vivo Imaging Systems<i>In vivo</i> imaging systems, including pre-clinical imaging systems and medical imaging systems are used to non-invasively visualize and capture images of live animals and plants. Monitor the natural processes or diseases of your subjects using small-animal pre-clinical imaging systems, including single photon positron emission tomography (SPECT), positron emission tomography (PET), computed tomography (micro-CT), magnetic resonance imaging (MRI), X-ray radiography, ultrasound, fluorescence and bioluminescence imagers. Multimodal systems and software solutions are also available for correlative analysis of organ, tissue, cell, or molecular-level processes. Find the best in vivo imaging products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Fluorescence Based AssayFluorescence based assays are widely used in life science research and high-throughput screening to measure a broad range of cellular activities.Small Animal ImagingSmall animal imaging is the visualization of living animals, most commonly mice and rats, for research purposes. This non-invasive technique is vital for long-term studies into drugs effects, as well as small animal anatomy and physiology.TumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.InflammationDrug Discovery & Development Screening