Combinatorial Variant Libraries

20 Jun 2019

Twist Bioscience’s unique capability to synthesize very large numbers of high quality oligos with our massively parallel silicon-based DNA synthesis platform, combined with our well established molecular biology expertise, allow the controlled fabrication of highly diverse gene mutant libraries with highly specific, user-defined, composition.

Combinatorial Libraries

Twist Bioscience

Unleash the full power of a well-designed library. With Twist Bioscience, you are assured that the library you design contains the specific modifications, exactly where you want them, saving you valuable resources for the downstream screening process.

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OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.Compound LibrariesCompound libraries, or chemical libraries, are used in drug discovery for the identification of potential therapeutics compounds. Used in conjunction with high-throughput screening, the libraries of stored compounds are often generated for specific purposes as a drug target or disease model. Cheminformatics are commonly used when designing a compound library and software can be used to analyze the screening process.  Library GenerationLibrary generation refers to the construction of NGS libraries from RNA and DNA sources.
Combinatorial Variant Libraries