ResourceSpectroscopy
Co-crystal screening: From smart design to effective experimentation
18 Mar 2022In this case study, Technobis Crystallization Systems details the use of two cutting-edge developments in the field of co-crystal screening. Download to explore the full process of how a febuxostat p-toluenesulfonic acid co-crystal was first predicted using a cutting-edge machine learning algorithm, and then subsequently obtained experimentally using the Crystal16 device.
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Technobis Crystallization SystemsUpgrade your crystallization screens with the New Industry Standard: The Crystal16 benchtop crystallization system.
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X-ray CrystallographyX-ray crystallography is an analytical technique used to determine the arrangement of atoms in a crystal. Monochromatic x-rays are produced from a synchrotron or x-ray generator. An x-ray crystallography system uses a detector to measure the x-ray diffraction from the crystal. The information is used to generate a 3D image of the crystal.Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Active PharmaceuticalsThe Active Pharmaceutical Ingredient (API) of a drug is the component that causes the direct effect of the product. The remaining inactive components are known as excipients.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.CrystallizationCrystallographyDrug Discovery & Development Screening