ResourceLife Sciences
Efficient chromatin removal in viral vector manufacturing using salt-active nucleases
3 Oct 2024The presence of chromatin-associated DNA in crude viral suspensions poses significant challenges for the downstream processing (DSP) of viral vectors. Peer-reviewed studies have demonstrated that M-SAN HQ excels in removing chromatin-associated DNA at physiological salt conditions, significantly outperforming traditional nucleases like Benzonase® and Denarase®. Explore how, together with SAN HQ for high salt conditions, ArcticZymes offers solutions specifically designed to meet the distinct needs of biomanufacturers.
Links
Tags
DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Viral Vectors