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Characterization of polymer degradation with SEC-MALS
3 Feb 2025Examine the power of size-exclusion chromatography coupled with multi-angle light scattering (SEC-MALS) for polymer characterization, using polydioxanone (PDO) surgical sutures as a case study. SEC-MALS provides precise measurements of molar mass, size, and distribution without relying on calibration standards. The study highlights key metrics for analyzing polymer degradation, showcasing SEC-MALS as an essential tool for assessing polymer stability and performance in medical applications.
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Size Exclusion ChromatographySize exclusion chromatography (SEC) is a liquid chromatographic technique used to separate and identify molecules based on their size, including polymers, proteins, nanoparticles & nucleic acid. SEC is further subdivided into gel filtration chromatography (GFC) and gel permeation chromatography (GPC) when an aqueous or organic mobile phase is used respectively. HPLC-based SEC systems and columns are available for analytical separation alongside SEC spin columns or filters to prep samples for many protocols. Find the best size exclusion chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.