BioLector XT Microbioreactor integrated with Biomek i5 Liquid Handler for automated bioprocess development

12 Jul 2024

In microbial process development the screening of several different process parameters is usually a bottleneck. The new integration of the BioLector XT microbioreactor with a Biomek i5 liquid handler allows for automated, high-throughput bioprocess development, leveraging the strength of both systems to expand strain screening and selection capabilities. Beckman Coulter Life Sciences highlights a screening study in which the integrated system provides full process control over microbial cultivations, while allowing for increased walk-away time. Using these capabilities, the study aimed to find an optimal strategy for an isopropyl β-D-1-thiogalactopyranoside (IPTG)-induced protein production process with Escherichia coli. Discover how he integration of the BioLector XT microbioreactor with the Biomek i5 liquid handler leverages the strengths of both systems to expand strain screening and selection capabilities for automated bioprocess development.

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Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.Automation Supplies / AccessoriesAutomated accessories and consumables make lab processes fast, efficient and reliable. Useful automation accessories include microplate sealers, label printers and reagent reservoirs.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.High-ThroughputEscherichia coli
BioLector XT Microbioreactor integrated with Biomek i5 Liquid Handler for automated bioprocess development of an IPTG-inducible E. coli strain