Bioinert coated hardware in oligonucleotide analysis

Oligonucleotides can modulate gene expression, offering potential treatments for various diseases. The rapidly growing field of therapeutic oligonucleotides requires robust analytical methods for quality and safety. Anion exchange chromatography (AEX) is suitable but often results in poor peak shape and low recovery due to oligonucleotide adsorption to column hardware. YMC Europe presents YMC Accura BioPro IEX QF columns, with bioinert coated hardware, enabling reliable and reproducible analyses. The BioPro IEX columns are based on porous and non-porous hydrophilic polymer beads with low nonspecific adsorption. YMC reports that they also show higher binding capacity and higher recovery of biomolecules compared to conventional ion exchange columns.