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Automated Hepatotoxicity Testing Using in vitro 3D Bioprinting

Agilent Technologies
27 Jun 2018

To meet the demand for increased hepatotoxicity testing, automation has been incorporated to streamline the procedure and reduce the need for large-scale manual manipulations. This application note describes how to combine liquid handling with a novel cell imaging multi-mode reader to perform automated 3D hepatotoxicity studies.

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Agilent BioTek Gen5 Software for Detection

Agilent Technologies

Agilent BioTek Gen5 software for Agilent BioTek multimode and single-mode microplate readers is an integrated tool for endpoint, kinetic, spectral scanning, and well area scanning. It controls all the functions of the plate reader and has powerful data analysis capabilities for a broad range of applications. Gen5 microplate reader software is also used to integrate BioTek plate readers to BioTek BioStack and other automated systems.

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Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.3D Printing3D printing is becoming an increasingly popular fixture in modern labs. From making bespoke equipment and replacing broken parts, to fabricating biological structures that imitate natural tissue characteristics, 3D printers can be used for a broad range of applications. 3D Cell CultureCulturing cells in three dimensions allows more physiologically relevant observations to be made regarding cellular interactions and gene expression. 3D models provide a more accurate representation of cells in vivo and are more stable than 2D cultures, making them very useful for long-term studies.HepatotoxicityHepatocytes

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Automated Hepatotoxicity Testing Using in vitro 3D Bioprinting