ResourceSpectroscopy
Analysis of subvisible and visible aggregation in lentiviral vectors with Aura GT
16 Oct 2024Third-generation lentiviral vectors (LVV) are promising nucleic acid delivery vehicles for cell and gene therapies. LVVs are more complex biomolecules compared to standard protein biologics. They are comprised of a lipid envelope, surface proteins, and nucleic acid material – all of which present challenges for physical and chemical stability. Discover how Aura GT™ requires as little as 5 µL of sample to quantitate and characterize visible and subvisible particles using backgrounded membrane imaging (BMI), and how the biological and chemical nature of large lentiviral aggregates can be identified using fluorescence membrane microscopy (FMM).
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Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.In Vivo Imaging Systems<i>In vivo</i> imaging systems, including pre-clinical imaging systems and medical imaging systems are used to non-invasively visualize and capture images of live animals and plants. Monitor the natural processes or diseases of your subjects using small-animal pre-clinical imaging systems, including single photon positron emission tomography (SPECT), positron emission tomography (PET), computed tomography (micro-CT), magnetic resonance imaging (MRI), X-ray radiography, ultrasound, fluorescence and bioluminescence imagers. Multimodal systems and software solutions are also available for correlative analysis of organ, tissue, cell, or molecular-level processes. Find the best in vivo imaging products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Lentivirus