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Analysis of Polychlorinated Biphenyls (PCBs) in Fish Oil Supplements by Gas Chromatography with Multi-Reflecting Time-of-Flight Mass Spectrometry (GC-MR-TOF-MS)

LECO Corp.
4 Apr 2011

In this application note by LECO, the contents of several over-the-counter fish oil capsules were spiked with Accustandard’s PCB congener standard, extracted into acetonitrile using Qsep Q150 extraction salts (Restek #26213), and analyzed using LECO’s Pegasus GC-HRT. At the heart of the new instrument is its TOF mass analyzer utilizing Folded Flight Path™ (FFP™) technology, with three convenient operational modes: nominal resolution, high resolution and ultra-high resolution. The GC-HRT provided the mass accuracy and high resolving power necessary for robust identification of trace components in fish oil matrices.

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Pegasus® GC-HRT

LECO Corp.

While some systems on the market offer users a choice between acquisition speed or resolution, the Pegasus GC-HRT provides scientists with an unprecedented combination of speed, resolution, mass accuracy, isotopic abundance, and dynamic range. This instrumentation utilizes LECO's own Folded Flight Path™ (FFP™) technology to allow users to achieve resolutions of up to 50,000. LECO's exclusive ChromaTOF-HRT™ software with Automated Peak Find and True Signal Deconvolution® provides seamless data handling and compatibility with the NIST Library.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Environmental Monitoring and TestingEnvironmental monitoring and testing uses handheld portable analyzers, kits, spectrometers or chromatography systems for air, water, soil, food and other sample testing. Useful features of analyzers such as BOD and COD include portability, easy calibration, automation and sensitivity.  Environmental test kits for pH, water, moisture, etc, should be accurate, sensitive, reliable, fast and easy to use.GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

Related resources

Analysis of Polychlorinated Biphenyls (PCBs) in Fish Oil Supplements by Gas Chromatography with Multi-Reflecting Time-of-Flight Mass Spectrometry (GC-MR-TOF-MS)