ResourceSpectroscopy

Analysis of pharmaceutical raw materials using the tri-range Spectrum 3 FT-IR Spectrometer

27 Mar 2023

Infrared Spectroscopy has become a ubiquitous tool in the analysis of pharmaceutical raw materials, with both mid- and near-infrared spectroscopy functioning as commonplace techniques for the investigation of both excipients and active pharmaceutical ingredients (APIs). Near-infrared spectroscopy is arguably the most common spectroscopic technique for the interrogation of incoming raw materials. Mid-infrared spectroscopy generally contains the most information regarding the chemical structure of an analyte, making it particularly useful for identification and analysis of active materials in pharmaceutical samples.

This application note describes how the PerkinElmer Spectrum 3™ FT-IR spectrometer together with the 21 CFR part 11 compliant Spectrum 10 software provides a high-performance solution for mid and near infrared analysis of materials used in the pharmaceutical industry.

Spectrum 3 FT-IR Spectrometer

PerkinElmer

From routine identification and verification to advanced research applications, you need the performance and flexibility to quickly, confidently, and cost effectively analyze a wide range of samples. The PerkinElmer Spectrum™ 3 FT-IR spectrometer provides the sampling flexibility and performance in mid, near, and far infrared ranges through a single instrument to advance research and new product development in academia, chemicals, polymers, and pharmaceuticals. The highly configurable platform provides dependable, consistent, and trouble-free operation through years of service. Spectrum 3 is loaded with a range of advanced innovations designed to provide you with exceptional performance and flexibility from the configuration you choose. Performance: Exceptional signal-to-noise ratio and photometric performance High reproducibility of spectral data without spectral interferences Best-in-class sensitivity, even when using room temperature detectors Characterize fast reactions with scan speed up to 100 scans/sec Optimize sensitivity and spectral resolution performance Flexibility: Maximize instrument uptime with a wide range of quickly interchangeable accessories Simplified TG-IR hyphenation experience from a single vendor Collaborate from any device, anywhere, any time with cloud connectivity Perform routine analyses faster with on-instrument SmartPanel Upgradeable to IR microscopy and imaging

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Infrared / IR SpectroscopyInfrared (IR) spectroscopy measures the interaction of infrared light with a sample, including transmission, reflectance & absorbance, facilitating the identification of analytes. Equipment used for quantitative analysis includes Fourier-transform infrared (FTIR) spectrometers, infrared cameras, FTIR gas analyzers, as well as attenuated total reflectance (ATR) accessories and pellet or film presses. Find the best IR spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Near Infrared SpectroscopyNear-infrared (NIR) spectroscopy measures the interaction of near-infrared light with a sample, including transmission, reflectance and absorbance, facilitating the identification of analytes. Measurements can be conducted using a Fourier-transform near infrared (FT-NIR) spectrometer, while there are also UV-Vis- NIR spectrophotometers that measure a broader spectrum of wavelengths. Find the best NIR spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Organic CompoundsOrganic compounds are carbon-based molecules that form the building blocks of life. These include hydrocarbons, lipids, proteins, and nucleic acids. Understanding organic compounds is crucial in chemistry, biochemistry, and pharmacology. Explore organic compound analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Infrared
Analysis of pharmaceutical raw materials using the tri-range Spectrum 3 FT-IR Spectrometer