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Analysis of PFAS by solid-phase extraction and LC-MS/MS

UCT, Inc.
12 Apr 2023

The significance of examining the levels of per- and polyfluoroalkyl substances (PFAS) in various matrices cannot be overstated. At present, two validated and published USEPA methods are available for examining PFAS in drinking water. In this application note, learn more about the analysis of 40 distinct PFASs in aqueous samples as per EPA 1633 3rd draft method by utilizing UCT Enviro-Clean® polymeric weak-anion exchange (WAX) SPE cartridges.

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Enviro-Clean DVB – PE Frits 500mg 6mL

UCT, Inc.

UCT's Enviro-Clean® Polymeric WAX Cartridges w/Polyethylene frits have been successfully utilized for the extraction of 26 diverse per- and polyfluoroalkyl substances (PFASs) in drinking water in addition to the 14 covered in the US EPA Method 537.  

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Solid-Phase ExtractionSolid-phase extraction (SPE) is used for clean-up, extraction and concentration of semi-volatile or non-volatile analytes from complex mixtures including blood, urine and food samples. Multiple formats are available for conducting SPE, including prepacked SPE cartridges, disks and microplates, as well as SPE sorbent powders for manual packing. SPE systems can be used to automate the process and extract multiple samples at once. Solid-phase microextraction (SPME) and supported liquid extraction (SLE) products are also available in the same formats. Find the best SPE, SLE and SPME equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Water AnalysisAnalytical methods used to test the purity of drinking water include determining the level of contaminants abides to the level set by the Environmental Protection Agency (EPA).Solid Phase Extraction (SPE)Solid phase extraction (SPE) is a sample preparation technique used to separate and concentrate analytes from complex mixtures. It is widely used in environmental, pharmaceutical, and clinical analysis. SPE provides higher sensitivity and selectivity compared to traditional liquid-liquid extraction methods, making it essential for accurate and reproducible results. Explore SPE tools and systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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