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Analysis of Isopropyl Alcohol (IPA) using Ultrasonic Nebulization with Membrane Desolvation and Quadrupole ICP-MS Detection

Teledyne Labs

Analysis of Isopropyl Alcohol (IPA) using Ultrasonic Nebulization with Membrane Desolvation and Quadrupole ICP-MS Detection

15 Sept 2015

Trace element measurement in organic solvents such as isopropyl alcohol (IPA) is an important application in the semiconductor industry. Inductively coupled plasma mass spectrometry (ICPMS) offers parts per trillion (ppt) and sub-ppt detection limits for many elements, but introduction of volatile organic solvents can present a number of problems: plasma instability and/or failure, carbon buildup on the sampling interface, and solvent-based mass spectral interferences. This application note demonstrates the use of the CETAC U6000AT+ Ultrasonic Nebulizer / Membrane Desolvator in stabilizing the plasma operation through removal of most of the diluting organic solvent during analyte transport.

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Atomic Absorption / Emission SpectroscopyAtomic absorption spectroscopy (AAS) and atomic emission spectroscopy (AES) — also called optical emission spectroscopy (OES) — are used to detect the elemental constituents in samples. Both techniques involve the atomization of a sample. Atomic absorption spectrometers may use a flame or furnace to create an atomic vapor of the sample before irradiation with spectral light. Optical emission spectrometers may use a flame, inductively coupled plasma (ICP), microwave plasma (MP) or spark arcs to atomize and excite the sample. At higher excitation energies, electrons can be emitted instead of photons, which can be useful for samples that can’t be atomized and for surface analysis. Explore electron spectroscopy equipment such as Auger spectrometers and photoelectron spectrometers for surface elemental analysis of samples. Find the best atomic absorption, photoelectron and optical emission spectrometers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Elemental AnalysisElemental analysis involves determining the elemental composition of a sample, often used in environmental, pharmaceutical, and material sciences. Techniques like ICP-MS, X-ray fluorescence, and atomic absorption spectroscopy allow precise quantification of elements such as metals and nonmetals in complex matrices. Browse our peer-reviewed product directory to find the best elemental analysis tools, compare products, check reviews, and get pricing directly from manufacturers.Solvent ReductionTrace Level ImpuritiesTrace level impurities refer to low concentrations of unwanted substances found in chemicals, pharmaceuticals, and other products. Detecting and removing these impurities is crucial for product safety and regulatory compliance. Explore trace impurity analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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