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Analysis of Drugs of Abuse by GC/MS Using Ultra Inert Universal Sintered Frit Liners

Agilent Technologies
14 Jul 2019

Gas chromatography/mass spectrometry (GC/MS) is a common screening technique for controlled substance analyses. Maintaining an inert flowpath is important in these analyses to prevent loss of peak shape and signal of the more sensitive or active compounds, such as amphetamine or oxycodone. In this application note, Agilent discusses how a sintered frit liner offers the same protection from complex nonvolatile matrices as glass wool liners, while avoiding wool breakage that may cause loss of peak response.

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GC/MS Forensic Toxicology Analyzer 

Agilent Technologies

GC/MS methods are widely used for forensic toxicology, especially for the screening of large numbers of target compounds in complex matrices. Full-scan EI methods offer many advantages for broad-range screening, such as an unlimited number of targets, full-spectrum identity confirmation, and library searching for identification of non-targets. Technologies such as Capillary Flow Technology backflushing, Deconvolution Reporting Software (DRS), and a toxicology library offer opportunities to increase the number of targets screened while reducing the time required per sample. Agilent GC/MS analyzers are ready to use and simplify startup. The analysis method makes use of the latest GC/MS technologies, improving productivity in the laboratory and producing consistent, high-quality data from day one.

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Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drugs of AbuseA drug of abuse is a drug that has been taken for non-medical purposes. Such drugs can have mind-altering effects, with some causing dependence and addiction.Drug TestingIt is essential to test the efficacy and toxicity of drugs at every stage of their development to ensure that a pharmaceutical product is fit for purpose and safe for use before reaching the stage of mass production and distribution.Forensic InvestigationForensic investigation is a diverse collection of scientific techniques and methods for the identification and characterization of chemicals relating to crime scene investigations.

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