Analysis of challenging pesticides regulated in the cannabis and hemp industry with the Agilent Intuvo 9000‑7010 GC/MS/MS system

A brief review of the United States individual state and Health Canada pesticides lists, which are regulated in the cannabis and hemp industries, reveals approximately 100 compounds that require identification and quantification. Of these, at least 29 compounds stand out as challenging to analyze using electrospray LC/MS/MS especially in the myriad of sample types that require analysis, for example, dry flowers, concentrates, oils, gummies, etc. In this application note, Agilent Technologies developed a novel GC/MS/MS method for the analysis of the five pesticides, known as the Fast-5, and demonstrated excellent accuracy, precision, limits of detection (LOD), limits of quantitation (LOQ), range, and linearity.