ResourceLife Sciences
An optimized protocol for the 2 mg/well Clarity OXT format plates
14 Sept 2023In this application note from Phenomenex, explore how oligonucleotides are becoming increasingly prominent in modern medicine due to their ability to modulate both gene expression and post-transcriptional splicing of introns and exons. Discover how the Spinraza®, a typical 2'-MOE-Gapmer chemistry antisense oligonucleotide, is being used in a new optimized protocol using the Clarity® OXT format plates.
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OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.