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Agilent Beam Enhancer Technology for High-Speed Transmission Raman Spectroscopy

Agilent Technologies
26 Feb 2019

Transmission Raman spectroscopy (TRS) is a powerful pharmaceutical analytical technique for whole-sample nondestructive capsule and tablet analysis. This Application Note describes a measurement speed increase of >10x, without increasing laser power, using an Agilent beam enhancer. With an enhancer, the active pharmaceutical ingredient % w/w in tablets was determined in as little as 10 ms.

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TRS100 Quantitative Pharmaceutical Analysis System

Agilent Technologies

The TRS100 enables fast, easy-to-use whole tablet or capsule content uniformity and polymorph screening for pharmaceutical finished-product testing and formulation development. Easier to implement than other spectroscopic methods, Agilent's transmission Raman spectroscopy (TRS) technology allows simple method development and deployment for quantitative analysis in quality control applications.

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Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Active PharmaceuticalsThe Active Pharmaceutical Ingredient (API) of a drug is the component that causes the direct effect of the product. The remaining inactive components are known as excipients.

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Agilent Beam Enhancer Technology for High-Speed Transmission Raman Spectroscopy