Advanced nuclease applications in lentiviral vector bioprocessing
8 Nov 2024Explore how alternative nucleases, salt active nuclease (SAN) and medium-salt active nuclease (M-SAN), are evaluated in lentiviral vector (LV) manufacturing to improve gene therapy product quality. Compared to traditional nucleases, SAN and M-SAN achieved enhanced vector recovery, reduced aggregation, and significantly lower residual DNA in the final product. These findings support the use of alternative nucleases to address critical quality needs in LV manufacturing.
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Bioprocessing Salt Active Nucleases - Physiological Conditions
ArcticZymesNonspecific endonuclease is highly active at physiological conditions (125–200 mM) for DNA removal during protein production, vaccine manufacturing, and viral vector preparation. M-SAN High Quality can be used directly in cell media, which improves efficiency and yield. Designed to replace Benzonase without workflow changes. M-SAN HQ excels in ensuring higher purity and efficiency. High purity (≥ 99%). Compatible with ELISA kit.