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Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances

SCIEX
4 Jun 2017

In forensic toxicology testing labs, workflows are trending. Routinely, labs have been tasked with doing targeted analysis, monitoring samples for a standard list of known drug compounds and quantifying any of those targeted compounds that are found. These days with the emergence of many different novel psychoactive substances (NPS), labs are being faced with the challenge to do more surveillance screening. This workflow looks for compounds that might be present in samples without any pre-existing knowledge of what those compounds could be.

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MasterView software is a powerful application that enables you to accurately screen unknown samples against the targeted list of compounds for quick identification, quantitation, and data review from complex mass spec data files. With MasterView software, laboratories can master the speed, power, and accuracy offered by LC-MS/MS technology. You can easily identify unknown compounds with greater confidence, using integrated library searching capabilities, formula finder, and fragmentation prediction tools to aid in true unknown structural elucidation. The product integrates both targeted and non-targeted data processing to make data review fast and straightforward with automated visual status indicators.  

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drugs of AbuseA drug of abuse is a drug that has been taken for non-medical purposes. Such drugs can have mind-altering effects, with some causing dependence and addiction.Compound IdentificationScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.Forensic InvestigationForensic investigation is a diverse collection of scientific techniques and methods for the identification and characterization of chemicals relating to crime scene investigations.

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