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Accurate Biological Testing for Amphetamine and Methamphetamine Abuse
Accurate Biological Testing for Amphetamine and Methamphetamine Abuse
18 Jan 2016This application note is an application newsletter from Sigma Aldrich which looks at the many applications of LC/MS, both in research and clinical use. The application note shows the features of many different pieces of equipment including the Astec® CHIROBIOTIC® V2 which can be found on the SelectScience website here.
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Astec CHIROBIOTIC™ V2 Chiral HPLC Column
Sigma-Aldrich SupelcoThe polar organic and the polar ionic modes have become increasingly popular largely because of their ideal compatibility with MS detection and preparative LC. Two years of extensive research at Astec in understanding these mechanisms has resulted in new possibilities for extending their effectiveness even further. Important changes in linkage chemistries and the silica and the silica have now led to the new CHIROBIOTIC V2 and T2 chiral stationary phases – columns of choice for those really difficult separations, and especially, for preparative LC. These new phases extend the capabilities of the series. They are designed to be used in the optimization process since they offer some distinct advantages in the polar ionic mode and polar organic mode. The standard CHIROBIOTIC phases remain the columns of choice for method development screening and for reversed phase separations. Read about the Astec CHIROBIOTIC being applied to Drug testing for Amphetamine and Methamphetamine Abuse here. Features: New extension for the CHIROBIOTIC series Enhanced selectivity and capacity in the polar organic mode and polar ionic mode Capacity increases of 2 to 20 fold over standard CHIROBIOTIC phases Most beneficial for basic molecules Neutral molecules can often be run in pure methanol
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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
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