A Superior Sample Preparation of Comprehensive Drug Panel Analytes from Oral Fluid Collection Devices

Drug testing in oral fluid has steadily gained popularity over other sample types such as urine and whole blood. One reason for this popularity is the easy non-intrusive sample collection procedure. Oral fluid collection devices often contain a device buffer, to prevent bacterial growth and increase the analytes stability during the sample transit to testing laboratories, but they may cause problems when performing LC/MS analyses. This application note presents a sample preparation procedure to significantly reduce the effects of the device buffer solution while maintaining a reproducible and consistent recovery of analytes.