A Rapid Screening Method to Identify Chemical Components of a Traditional Herb using the Novel Informatics UNIFI Platform

A Rapid Screening Method to Identify Chemical Components of a Traditional Herb using the Novel Informatics UNIFI Platform

5 Jan 2016

This poster demonstrates the use of UPLC/QTof-MS coupled to NPAS with UNIFI for the identification of total material base including target and non-target ingredients. The efficacy of traditional Chinese medicine has been affirmed by thousands of years of history as well as by modern clinical practice. However, understanding the material base, especially to rapidly identify all of the chemical components and determining their method of efficacy, still poses a challenge.

Xevo G2-XS QTof

Waters

Xevo G2-XS QTof - eXtreme Sensitivity, eXtraordinary Selectivity, eXceptional Solutions. For the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples the Xevo G2-XS QTof provides maximum robustness with no compromise in performance, class-leading real-world quantitative sensitivity, the highest quality, most comprehensive qualitative information, flexibility to adapt to changing needs and is accessible to experts and non-experts alike.

(17)

Natural Products Application Solution with UNIFI

Waters

The Waters Natural Products Application Solution with UNIFI provides a bottleneck breakthrough solution for analyzing natural products. Built around the UNIFI Scientific Information System, it converts traditionally labor intensive and cumbersome multistep sample profiling procedures into a workflow-driven and significantly streamlined process. It incorporates a unique Traditional Medicine Library into the workflow, along with automatic fragment ion confirmation implementation. As a result, the process of ingredient profiling can move from data acquisition to review of a completed analysis with the click of a button. The solution also provides users with test samples, user-required analytical method templates, and comprehensive workflow templates. All is managed into an easy-to-use solution that minimizes technical requirements for analysts.

(1)

Links

Tags

UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.Natural ProductsTargeted ScreeningNon-Targeted Screening