A Novel Three-Dimensional Glioma Blood Brain Barrier Model for High-Throughput Testing of Tumoricidal Capability
9 May 2018The blood brain barrier, BBB, acts as a defense preventing foreign particulates and pathogens from entering the brain's vascular system. This poster demonstrates the development of a three-dimensional model to study BBB transport and drug cytotoxicity, developed using Corning® 96-well spheroid microplates and the Corning HTS transwell®-96 tissue culture system.
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Corning® 384-well Black/Clear Round Bottom Ultra-Low Attachment Spheroid Microplate, Bulk Packed 10 per Bag, with Lid, Sterile
Corning Life SciencesUltra-Low Attachment microplates feature a covalently bound hydrogel layer that effectively inhibits cellular attachment Surface minimizes protein absorption, enzyme activation and cellular activation Surface is noncytotoxic, biologically inert and nondegradable Sterilized by gamma irradiation Black wall microplates have low background fluorescence, minimal light scatter and reduced crosstalk Opaque walls to prevent well-to-well crosstalk Can be used for both top and bottom reading instruments Bulk packed 10 per bag Novel well geometry aids formation of spheroids in center of well Optically clear round bottom with black opaque microplate body