ResourceLife Sciences
A Novel Microliver Production Technology for High-Throughput Livertox Screening Systems
10 Feb 2015Primary hepatocytes are commonly used to study drug metabolism, enzyme induction and compound hepatoxicity. To mimic a more natural environment, InSphero developed a new scaffold-free, organotypic production technology for 3-dimensional hepatic microtissues. This study demonstrates the validity and suitability of the GravityPlus hanging drop platform for liver microtissue culture, offering a highly functional and reliable in vitro toxicology testing system which can be easily implemented into standard lab automation processes.
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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Hepatotoxicity