ResourceSpectroscopy
A Label-Free, Multi-Omic Study to Qualitatively and Quantitatively Characterize the Effects of a Glucosylceramide Inhibitor on Obesity
2 Oct 2014This application note describes a label-free, multi-omic approach to investigate the effects of a glucosylceramide inhibitor for the treatment of obesity. Progenesis® QI and Progenesis QI Proteomics Software enables a seamless workflow, from LC-MS data processing and database searching to pathway interrogation, implicating carbohydrate metabolism, and molecular transport networks in the compound’s mechanism of action.
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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Software PlatformsSoftware platforms are useful for various stages of laboratory experiments from data collection to data storage and processing. For instance lab software is available for system control, data management, data analysis and qualification / validation.ProteomicsProteomics refers to the analysis of proteins through a variety of different experiments in order to understand structure and functionality. Typical techniques include protein purification and mass spectrometry. Label-Free AnalysisCarbohydrates